Antibody-based Protein Profiling of the Human Chromosome 21
نویسندگان
چکیده
منابع مشابه
Antibody-based proteomics for human tissue profiling.
Here, we describe the use of antibody-based proteomics involving the generation of protein-specific antibodies to functionally explore the human proteome. The antibodies can be used for analysis of corresponding proteins in a wide range of assay platforms, including i) immunohistochemistry for detailed tissue profiling, ii) specific affinity reagents for various functional protein assays, and i...
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Many disease biomarkers are expressed at relatively low levels or are not secreted making them difficult to detect in serum or plasma. However, these biomarkers can stimulate a robust humoral immune response even if the antigens are expressed at very low levels. Because the immune system serves as a natural amplification system, antibodies to these biomarkers can be produced at detectable level...
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Chromosome 21 is the smallest autosome, comprising only about 1.9% of human DNA, but represents one of the most intensively studied regions of the genome. Much of the interest in chromosome 21 can be attributed to its association with Down's syndrome, a genetic disorder that afflicts one in every 700 to 1000 newborns. Although only 17 genes have been assigned to chromosome 21, a very large numb...
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Comparison of human sequences with the DNA of other mammals is an excellent means of identifying functional elements in the human genome. Here we describe the utility of high-density oligonucleotide arrays as a rapid approach for comparing human sequences with the DNA of multiple species whose sequences are not presently available. High-density arrays representing approximately 22.5 Mb of nonre...
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ژورنال
عنوان ژورنال: Molecular & Cellular Proteomics
سال: 2012
ISSN: 1535-9476
DOI: 10.1074/mcp.m111.013458